刘华伟

    博士、讲师

    学习工作经历

2021.7-至今      西南大学，讲师

2018.7-2021.6  西南大学，博士后

2012.9-2018.6  西南大学，生物化学与分子生物学专业，硕博连读，理学博士

2008.9-2012.6  河南大学，生物技术专业，本科，理学学士

    研究领域

   1.家蚕先天免疫调控机制研究；

    鉴定并调查了家蚕clip丝氨酸蛋白酶的种类和表达模式，研究这类蛋白酶在家蚕生长发育和先天免疫过程中的功能，阐明serpin类蛋白酶抑制剂对家蚕先天免疫的调控机制。

    2.家蚕变态蜕皮机制研究；

     对家蚕变态蜕皮期的表皮和蜕皮液进行了转录组和蛋白质组分析，鉴定并研究新的转录因子及丝氨酸蛋白酶等在蜕皮过程中的功能及调控作用。

    成果情况

    代表性论文/论著

1) Liu H W, Wang L L, Tang X, Dong Z M, Guo P C, Zhao D C, Xia Q Y, Zhao P*. Proteomic analysis of Bombyx mori molting fluid: Insights into the molting process. Journal of Proteomics, 2018, 173:115-125.

2) Liu H W, Wang L L, Meng Z, Tang X, Li Y S, Xia Q Y, Zhao P*. A clip domain serine protease involved in moulting in the silkworm, Bombyx mori: cloning, characterization, expression patterns and functional analysis. Insect Mol. Biol, 2017, 26(5):507-521.

3) Liu H W, Li Y S, Tang X, Guo P C, Wang D D, Zhou C Y, Xia Q Y, Zhao P*. A midgut-specific serine protease, BmSP36, is involved in dietary protein digestion in the silkworm, Bombyx mori. Insect Sci, 2017, 24(5):753-767.

4) 刘华伟, 李游山, 唐新, 张晓璐, 赵萍*. 家蚕丝氨酸蛋白酶BmSP141的表达特征及对饥饿的响应. 中国农业科学, 2016, 49(6):1207-1218.

5) Wang L L, Liu H W, Fu H Y, Zhang L, Guo P C, Xia Q Y, Zhao P*. Silkworm serpin32 functions as a negative-regulator in prophenoloxidase activation. Dev Comp Immunol, 2019, 91:123-131.

6) Li Y S, Liu H W, Zhu R, Xia Q Y, Zhao P*. Loss of second and sixth conserved cysteine residues from trypsin inhibitor-like cysteine-rich domain-type protease inhibitors in Bombyx mori may induce activity against microbial proteases. Peptides, 2016, 86:13-23.

7) Tang X, Liu H W, Chen Q M, Wang X, Xiong Y, Zhao P*. Genome-wide identification, characterization and expression analysis of the solute carrier 6 gene family in silkworm (Bombyx mori). Int J Mol Sci, 2016, 17(10).

8) Li Y S, Liu H W, Zhu R, Xia Q Y, Zhao P*. Protease inhibitors in Bombyx mori silk might participate in protecting the pupating larva from microbial infection. Insect Sci, 2016, 23(6):835-842.

9) Li Y S, Zhao P, Liu H W, Guo X M, He H W, Zhu R, Xiang Z H, Xia Q Y*. TIL-type protease inhibitors may be used as targeted resistance factors to enhance silkworm defenses against invasive fungi. Insect Biochem. Mol. Biol, 2015, 57:11-9.

10) Li Y S, Dong Z M, Liu H W, Zhu R, Bai Y, Xia Q Y, Zhao P*. The fungal-resistance factors BmSPI38 and BmSPI39 predominantly exist as tetramers, not monomers, in Bombyx mori. Insect Mol. Biol, 2018, 27(6):686-697.

        联系方式

      Email：hwliu096@swu.edu.cn