研究员、博士生导师

重庆市人才集聚计划

简历：

1998-2002              北京林业大学       本科

2002-2007              清华大学         博士

2008-2012              美国西南医学中心     博士后

2012-                      西南大学         研究员

主要科研领域与方向：

1. 蚕丝蛋白的合成与调控

2. 家蚕生长发育性状调控

3. 蚕丝新材料开发与利用

科学成就：

主要从事蚕丝蛋白的合成与调控、家蚕生长发育性状调控与蚕丝新材料开发与利用研究，现任重庆市蚕丝纤维新材料工程技术研究中心副主任，智利国家科学技术委员会、国家自然科学基金委、国家留学基金委、教育部学者计划、博士学位论文、国家博士后基金、浙江省、重庆市、河北省、广西自治区基金等评审专家，重庆市高校创新团队研究骨干。

近年来，主持国家自然科学基金面上项目、重庆市自然科学基金重点项目、中央高校基本科研业务费创新团队项目、重点项目、西南大学博士基金、生物大分子国家重点实验室开放基金等多项，指导学生主持重庆市研究生科研创新项目6项，中央高校基本业务费“学生双创项目”5项。主研美国自然科学基金（NIH R01）、美国心脏病协会基金、美国Welch基金、国家重点基础研究发展计划（973计划）、国家自然科学基金重点项目、国家自然科学基金青年项目、重庆市自然科学基金、中央高校基本科研业务费、西南大学博士基金等。在PNAS、elife、Science signaling、Molecular and Cellular Biology、Biophysical Journal、Insect Biochemistry and Molecular Biology等国际学术刊物发表论文40余篇。

代表性论文/论著：

[1]  Huawei He, Taehong Yang, Jonathan R. Terman & Xuewu Zhang. Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration. Proc. Natl. Acad. Sci. U.S.A. 2009 106(37):15610-5.

[2]     Yuxiao Wang^#, Huawei He^#, Nishi Srivastava, Sheikh Vikarunnessa, Yong-bin Chen, Jing Jiang, Christopher W. Cowan & Xuewu Zhang. Plexins are GTPase Activating Proteins for Rap and are Activated by Induced Dimerization. Science signaling. 2012 5(207): ra6 (^#, co-first author).

[3]     Yuxiao Wang^#, Heath G. Pascoe^#, Chad A. Brautigam, Huawei He, and Xuewu Zhang. Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin. eLife2013 2:e01279.

[4]     Hua X, Li B, Song L, Hu C, Li X, Wang D, Xiong Y, Zhao P, He H*, Xia Q*, Wang F*. Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-κB activation. Journal of Biological Chemistry. 2018 Jul 27;293(30):11878-90.

[5]     H. He*, G. Tao, Y. Wang, R. Cai, P. Guo, L. Chen, H. Zuo, P. Zhao, Q. Xia, In situ green synthesis and characterization of sericin-silver nanoparticle composite with effective antibacterial activity and good biocompatibility, Materials Science and Engineering: C 80 (2017) 509-516.

[6]     He, Huawei*, Rui Cai, Yejing Wang, Gang Tao, Pengchao Guo, Hua Zuo, Liqun Chen, Xinyu Liu, Ping Zhao, and Qingyou Xia. "Preparation and characterization of silk sericin/PVA blend film with silver nanoparticles for potential antimicrobial application." International journal of biological macromolecules 104 (2017): 457-464.

[7]      Liu, Liying, Rui Cai, Yejing Wang, Gang Tao, Lisha Ai, Peng Wang, Meirong Yang, Hua Zuo, Ping Zhao, and Huawei He*. "Polydopamine-Assisted Silver Nanoparticle Self-Assembly on Sericin/Agar Film for Potential Wound Dressing Application." International journal of molecular sciences 19, no. 10 (2018): 2875.

[8]      Yang, Meirong, Yejing Wang, Gang Tao, Rui Cai, Peng Wang, Liying Liu, Lisha Ai, , Hua Zuo, Ping Zhao, Ahmad Umar, Chuanbin Mao, Huawei He*. "Fabrication of Sericin/Agrose Gel Loaded Lysozyme and Its Potential in Wound Dressing Application." Nanomaterials 8, no. 4 (2018): 235.

[9]       Wang, Yejing, Rui Cai, Gang Tao, Peng Wang, Hua Zuo, Ping Zhao, Ahmad Umar, and Huawei He*. "A novel AgNPs/sericin/agar film with enhanced mechanical property and antibacterial capability." Molecules 23, no. 7 (2018): 1821.

[10]      Liu, Liying, Rui Cai, Yejing Wang, Gang Tao, Lisha Ai, Peng Wang, Meirong Yang, Hua Zuo, Ping Zhao, Hong Shen, Ahmad Umar, Huawei He*. "Preparation and characterization of AgNPs in situ synthesis on polyelectrolyte membrane coated sericin/agar film for antimicrobial applications." Materials 11, no. 7 (2018): 1205.

[11]      Li, Yu, Yejing Wang, Kai Song, Lina Liu, Rui Cai, Gang Tao, Ping Zhao, Haimeng Zhou, and Huawei He*. "A rapid and sensitive colorimetric assay for the determination of adenosine kinase activity." Biochemical and biophysical research communications (2018).

[12]      Yang, Meirong, Yejing Wang, Rui Cai, Gang Tao, Huaipu Chang, Chaoxiang Ding, Hua Zuo, Hong Shen, Ping Zhao, Huawei He*. "Preparation and Characterization of Silk Sericin/Glycerol Films Coated with Silver Nanoparticles for Antibacterial Application." Science of Advanced Materials 10, no. 6 (2018): 761-768.

[13]      Guo, Peng-Chao, Qian Wang, Zhan Wang, Zhaoming Dong, Huawei He, and Ping Zhao. "Biochemical characterization and functional analysis of invertase Bmsuc1 from silkworm, Bombyx mori." International journal of biological macromolecules 107 (2018): 2334-2341.

[14]      Tao, Gang, Rui Cai, Yejing Wang, Kai Song, Pengchao Guo, Ping Zhao, Hua Zuo, and Huawei He*. "Biosynthesis and characterization of AgNPs–silk/PVA film for potential packaging application." Materials 10, no. 6 (2017): 667.

[15]      Cai, Rui, Gang Tao, Huawei He*, Pengchao Guo, Meirong Yang, Chaoxiang Ding, Hua Zuo, Lingyan Wang, Ping Zhao, and Yejing Wang. "In situ synthesis of silver nanoparticles on the polyelectrolyte-coated sericin/pva film for enhanced antibacterial application." Materials 10, no. 8 (2017): 967.

[16]      Cai, Rui, Gang Tao, Huawei He, Kai Song, Hua Zuo, Wenchao Jiang, and Yejing Wang. "One-step synthesis of silver nanoparticles on polydopamine-coated sericin/polyvinyl alcohol composite films for potential antimicrobial applications." Molecules 22, no. 5 (2017): 721.

[17]      Zhang, Quan, Tingcai Cheng, Shengkai Jin, Youbing Guo, Yuqian Wu, Duolian Liu, Xiaomin Xu, Yueting Sun, Zhiqing Li, Huawei He, Qingyou Xia. "Genome-wide open chromatin regions and their effects on the regulation of silk protein genes in bombyx mori." Scientific reports 7, no. 1 (2017): 12919.

[18]      Liu, Lina, Yu Li, Yejing Wang, Peng Zhao, Shuguang Wei, Zhenzhen Li, Huaipu Chang, and Huawei He*. "Biochemical characterization and functional analysis of the POU transcription factor POU-M2 of Bombyx mori." International Journal of Biological Macromolecules (2016): 701-708.

[19]      Liu, Lina, Yejing Wang, Yu Li, Ying Lin, Yong Hou, Yan Zhang, Shuguang Wei, Peng Zhao, Ping Zhao, and Huawei He*. "LBD1 of vitellogenin receptor specifically binds to the female-specific storage protein SP1 via LBR1 and LBR3." PLoS one 11, no. 9 (2016): e0162317.

[20]      Tao, Gang, Lina Liu, Yejing Wang, Huaipu Chang, Ping Zhao, Hua Zuo, and Huawei He*. "Characterization of Silver Nanoparticle In Situ Synthesis on Porous Sericin Gel for Antibacterial Application." Journal of Nanomaterials (2016).

[21]      Tao, Gang, Yejing Wang, Lina Liu, Huaipu Chang, Ping Zhao and Huawei He*. " Preparation and characterization of silver nanoparticles composited on polyelectrolyte film coated sericin gel for enhanced antibacterial application." Science of advanced materials (2016).

[22]      Meng, Mei, Huawei He, Jing Xiao, Ping Zhao, Jiale Xie and Zhisong Lu. "Controllable in situ synthesis of silver nanoparticles on multilayered film-coated silk fibers for antibacterial application." Journal of colloid and interface science 461 (2016): 369-375.

[23]      Tan, Jia‐Lian, Ting‐Ting Yang, Yu Liu, Xue Zhang, Shu‐Jin Cheng, Hua Zuo and Huawei He*. "Sensitive detection of strong acidic condition by a novel rhodamine‐based fluorescent pH chemosensor." Luminescence (2015).

[24]      Kulak, Ozlem, Hua Chen, Brody Holohan, Xiaofeng Wu, Huawei He, Dominika Borek, Zbyszek Otwinowski et al. "Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells." Molecular and cellular biology 35, no. 14 (2015): 2425-2435.

[25]      Guo, Peng-Chao, Zhaoming Dong, Ping Zhao, Yan Zhang, Huawei He, Xiang Tan, Weiwei Zhang, and Qingyou Xia. "Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18." Scientific reports 5 (2015).

[26]      Li, Youshan, Ping Zhao, Huawei Liu, Xiaomeng Guo, Huawei He, Rui Zhu, Zhonghuai Xiang, and Qingyou Xia. "TIL-type protease inhibitors may be used as targeted resistance factors to enhance silkworm defenses against invasive fungi." Insect biochemistry and molecular biology 2015 57:11-19.

[27]      Guo, Peng-Chao, Zhaoming Dong, Li Xiao, Tao Li, Yan Zhang, Huawei He, Qingyou Xia, and Ping Zhao. "Silk gland-specific proteinase inhibitor serpin16 from the Bombyx mori shows cysteine proteinase inhibitory activity." Biochemical and biophysical research communications 457, no. 1 (2015): 31-36.

[28]      Wang, Yejing, Huawei He*, Lina Liu, Chunyan Gao, Shui Xu, Ping Zhao, and Qingyou Xia. "Inactivation and Unfolding of Protein Tyrosine Phosphatase from Thermus thermophilus HB27 during Urea and Guanidine Hydrochloride Denaturation." PLoS One 2014 9(9): e107932.

[29]      Chen, Zhe^#, Xiang-Jun Chen^#, Mengdie Xia^#, Hua-Wei He^#, Sha Wang, Huihui Liu, Haipeng Gong, and Yong-Bin Yan. "Chaperone-Like Effect of the Linker on the Isolated C-Terminal Domain of Rabbit Muscle Creatine Kinase." Biophysical Journal. 2012 103(3): 558-66.

[30]      Yejing Wang, Huawei He, Sen Li. Effect of Ficoll 70 on Thermal Stability and Structure of Creatine Kinase. Biochemistry (Moscow). 2010 75(5):648-54.

[31]      Zhu Jiang, He Hua-Wei, Li Sen. Macromolecular crowding enhances thermal stability of rabbit muscle creatine kinase. Tsinghua Science and Technology. 2008 13(4):454-9.

[32]      He Hua-Wei^#, Feng Shan^#, Pang Min, Zhou Hai-Meng, Yan Yong-Bin. Role of the linker between the N- and C-terminal domains in the stability and folding of rabbit muscle creatine kinase. Int. J. Biochem. Cell Biol. 2007 39(10):1816-27.

[33]      He Hua-Wei^#, Li Jie^#, Zhao Tong-Jin, Ma Yong, Shi Feng, Zhou Hai-Meng. Exploration of the polar microenvironment around the reactive cysteine in rabbit muscle creatine kinase. Int. J. Biol. Macromol. 2007 41(4):361-8.

[34]      Shi Feng^#, Zhao Tong-Jin^#, He Hua-Wei, Li Jie, Zeng Xian-Gang, Zhou Hai-Meng, Wu Ping. Sodium barbital is a slow reversible inactivator of rabbit-muscle creatine kinase. Biochem. Cell Biol. 2006 84(2):142-7.

[35]      Zhang Jun, He Hua-Wei, Wang Qi, Yan Yong-Bin. Sequential events in ribonuclease A thermal unfolding characterized by two-dimensional infrared correlation spectroscopy. Protein Pept. Lett. 2006 13(1):33-40.

[36]      Yan Yong-Bin, Zhang Jun, He Hua-Wei, Zhou Hai-Meng. Oligomerization and aggregation of bovine pancreatic ribonuclease A: characteristic events observed by FTIR spectroscopy. Biophys. J. 2006 90(7):2525-33.

[37]      He Hua-Wei, Zhang Jun, Zhou Hai-Meng, Yan Yong-Bin. Conformational change in the C-terminal domain is responsible for the initiation of creatine kinase thermal aggregation. Biophys. J. 2005 89(4):2650-8.

[38]      Meng Fan-Guo, Hong Yuan-Kai, He Hua-Wei, Lyubarev A. E., Kurganov B. I., Yan Yong-Bin, Zhou Hai-Meng. Osmophobic effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys. J. 2004 87(4):2247-54.

[39]      Yan Yong-Bin, Wang Qi, He Hua-Wei, Zhou Hai-Meng. Protein thermal aggregation involves distinct regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin. Biophys. J.2004 86(3):1682-90.

[40]      Yan Yong-Bin, Wang Qi, He Hua-Wei, Hu Xin-Yao, Zhang Ri-Qing, Zhou Hai-Meng. Two-dimensional infrared correlation spectroscopy study of sequential events in the heat-induced unfolding and aggregation process of myoglobin. Biophys. J. 2003 85(3):1959-67.

联 系 地 址：重庆市北碚区西南大学（南区）家蚕基因组生物学国家重点实验室，400716

电    话：023-68251575

E-mail   ：hehuawei@swu.edu.cn