钱文良

     副教授

     学习工作经历

     2020.07-至今       西南大学生物学研究中心，副教授

     2018.01-2020.06 西南大学博士后

     2012.07-2017.12 西南大学硕博连读，理学博士

     2008.09-2012.06 吉林农业大学，工学学士

     研究领域

    （1）家蚕遗传和发育研究：重点关注蜕皮激素信号通路关键分子BR-C的翻译后修饰调控；鉴定家蚕BR-C新靶标基因及功能分析；解析家蚕BR-C在变态发育期脂代谢过程中的关键作用。

    （2）细胞核内复制的发生机制研究：解析Fzr调节家蚕丝腺和果蝇唾液腺细胞核内复制进程的分子机制；探索通过改变家蚕丝腺核内复制提高蚕丝蛋白产量的靶标。

     成果情况

     代表性论文/论著

    1. Wenliang Qian, Xiaoxu Gang, Tianlei Zhang, Ling Wei, Xinxin Yang, Zheng Li, Yan Yang, Liang Song, Peng Wang, Jian Peng, Daojun Cheng*, and Qingyou Xia*. Protein kinase A-mediated phosphorylation of the Broad-Complex transcription factor in silkworm suppresses its transcriptional activity. J Biol Chem. 2017, 28; 292(30):12460-12470.

     2. Wenliang Qian, Lixia Kang, Tianlei Zhang, Meng Meng, Yonghu Wang, Zhiqing Li, Qingyou Xia*, and Daojun Cheng*. Ecdysone Receptor (EcR) Is Involved in the Transcription of Cell Cycle Genes in the Silkworm. Int J Mol Sci. 2015 Feb; 16(2): 3335–3349.

     3. Daojun Cheng#, Wenliang Qian#, Yonghu Wang, Meng Meng, Ling Wei, Zhiqing Li, Lixia Kang, Jian Peng, and Qingyou Xia*. Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1. PLoS One. 2014; 9(10): e109111.

     4. Daojun Cheng#, Wenliang Qian#, Meng Meng, Yonghu Wang, Jian Peng, and Qingyou Xia*. Identification and expression profiling of the BTB domain-containing protein gene family in the silkworm, Bombyx mori. Int J Genomics. 2014; 2014: 865065.

     5. Peng Wang, Wenliang Qian, Weina Wang, Mengpei Guo, Qingyou Xia1, Daojun Cheng*. Identification and characterization of the Anillin gene in silkworm. DNA Cell Biol. 2019.4660.

     6. Tianlei Zhang#, Wei Song #, Zheng Li #, Wenliang Qian, Ling Wei, Yan Yang, Weina Wang, Xuan Zhou, Meng Meng, Jian Peng, Qingyou Xia*, Norbert Perrimon*, Daojun Cheng*. Kruppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes. Proc Natl Acad Sci USA, 2018.04.10, 115(15): 3960~3965

     7. Xiaoxu Gang, Wenliang Qian, Tianlei Zhang, Xinxin Yang, Qingyou Xia, and Daojun Cheng*. Aurora B kinase is required for cell cycle progression in silkworm. Gene. 2017 Jan 30;599:60-67.

     8. Meng Meng, Daojun Cheng, Jian Peng, Wenliang Qian, Jiarui Li, Dandan Dai, Tianlei Zhang, and Qingyou Xia*. The homeodomain transcription factors Antennapedia and POU-M2 regulate the transcription of the steroidogenic enzyme gene Phantom in the silkworm. J Biol Chem. 2015, 2; 290(40): 24438–24452.

联系方式

Email：wenliang20081103@126.com