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博士，助理研究员。

简历：

主要科研领域与方向:

科研领域：结构生物学、生物化学与分子生物学

研究方向：1）研究家蚕中抗菌蛋白的结构，抗菌机制，及医学应用转化。2）研究蛋白酶和抑制剂在丝腺发育过程中参与的调控作用，构建丝腺发育过程中的丝蛋白稳定/降解的调控网络。

科学成就：

先后主持国家自然科学基金、国家博士后基金特别项目、国家博士后基金面上项目重庆市基础与前沿研究技术项目和教育部中央高校科研业务费等，并作为主研人员参与了国家973、863等重大课题。已在J Biol Chem、Sci Rep等知名杂志上发表SCI论文十余篇。

代表性论文/论著：

[1]. Guo, P. C. §, Dong, Z.M. §, Zhao P., Zhang, Y., He, H. W., Tan, X., Zhang, W. W., and Xia, Q. Y.# Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18. Sci Rep. 2015, 5:11863.

[2]. Guo, P. C., Ma, J. D., Jiang, Y. L., Wang, S. J., Bao, Z. Z., Yu, X. J., Chen, Y., and Zhou, C. Z.# Structure of yeast sulfhydryl oxidase Erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space. J Biol Chem. 2012, 287, 34961-34969

[3]. Guo, P.C., Dong, Z., Xiao, L., Li, T., Zhang, Y., He, H., Xia, Q., and Zhao, P.# Silk gland-specific proteinase inhibitor serpin16 from the Bombyx mori shows cysteine proteinase inhibitory activity. Biochem Biophys Res Commun. 2015, 457, 31-36.

[4]. Guo, P.C., Bao, Z. Z., Ma, X. X., Xia, Q. and Li, W. F.# Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal reductase Gre2. Biochim Biophys Acta. 2014, 1844, 1486-1492.

[5]. Guo, P. C., Zhou, Y. Y., Ma, X. X. and Li, W. F. # Structure of Hsp33/YOR391Cp from the yeast Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011, 66, 1557-1561

[6]. Ma, X. X., Guo, P. C., Shi, W. W., Luo, M., Tan, X. F., Chen, Y. and Zhou, C. Z. # Structural plasticity of the thioredoxin recognition site of yeast methionine S-sulfoxide reductase Mxr1. J Biol Chem. 2011, 286, 13430-13437

[7]. Guo, P. C., Ma, X. X., Bao, Z. Z., Ma, J. D., Chen, Y. and Zhou, C. Z.# Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1. J Struct Biol. 2011, 176, 112-118.

[8]. Hu, X. Q.§, Guo, P. C.§, Ma, J. D. and Li, W. F.# Structures of Saccharomyces cerevisiae D-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013, 69, 1190-1195

[9]. Chen, B. Y. §, Ma, X. X. §, Guo, P. C., Tan, X., Li, W. F., Yang, J. P., Zhang, N. N., Chen, Y., Xia, Q. and Zhou, C. Z. # Structure-guided activity restoration of the silkworm glutathione transferase Omega GSTO3-3. J Mol Biol. 2011, 412, 204-211

[10]. Pu, Y. G., Jiang, Y. L., Ye, X. D., Ma, X. X., Guo, P. C., Lian, F. M., Teng, Y. B., Chen, Y. and Zhou, C. Z. # Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. J Struct Biol. 2011, 175, 469–474

[11]. Dong, Z.M., Zhao P., Zhang, Y., Song, Q.R., Zhang, X.L., Guo, P. C., Wang, D.D., Xia, Q. Y. # Analysis of proteome dynamics inside the silk gland lumen of Bombyxmori. Sci Rep. 2016, 6:11863

[12]. Zhang, Y., Zhao P., Dong, Z.M., Wang, D.D., Guo, P. C., Guo, X. M., Song, Q.R., Zhang, W.W., Xia, Q.Y. # Comparative proteome analysis of multi-layer cocoon of the silkworm, Bombyx mori. PLoS One, 2015,10 (4):e0123403-e0123403

联系地址：重庆市北碚区西南大学（南区）家蚕基因组生物学国家重点实验室，400716

电话：023-68251520

传真：

E-mail：guopc@swu.edu.cn