姓名：王根洪
副研究员、硕士生导师
简历：
1999-2003 | 西南农业大学 | 本科生 |
2003-2008 | 西南农业大学 | 博士生（硕博连读） |
2008-2012 | 重庆大学农学及生命科学研究院 | 讲师 |
2014-2016 | 康奈尔大学BTI研究所 | 访问学者 |
2012.03-至今 | 西南大学家蚕基因组生物学国家重点实验室 | 副研究员 |
主要科研领域与方向:
昆虫-生物互作机制研究；家蚕抗病抗逆分子机制研究；动植物遗传工程。
科学成就：
创建了基于转基因RNAi和增量表达抗病毒蛋白的家蚕抗病分子育种平台技术，制作获得了对家蚕核型多角体病毒（BmNPV）具有增强抗性的转基因家蚕素材数个。
作为家蚕基因组研究团队成员，参加了家蚕基因组计划及家蚕全基因组芯片的研制。参加了“十一五”、“十二五”家蚕“973”、“863”、“948”项目及国家自然科学基金及省部级等项目数项，主持国家自然科学基金，中央高校科研业务费等科研项目10余项。近年来已在国内外高水平期刊发表论文30余篇，参与编写专著2部；获得专利授权3 项，申请专利2项。
代表性论文：
1. Genhong Wang, Liang Jiang, Li Zhu, Ting-Cai Cheng, Wei-Huan Niu, Ya-Fei Yan and Qing-You Xia.(2013). “Characterization of Argonaute family members in the silkworm, Bombyx mori.” Insect Science. 00:1-14.
2. Genhong Wang, Chun Liu, Xing-fu Zha, Jie Chen, Liang Jiang and Q.-y. Xia. (2008). "Cathepsin B protease is required for metamorphism in silkworm, Bombyx mori." Insect Science 15: 201-208.
3. Genhong Wang, Qing-You Xia, Dao-Jun Cheng, Jun Duan, Ping Zhao, Jie Chen and Z. Li. (2008). "Reference genes identified in the silkworm Bombyx mori during metamorphism based on oligonucleotide microarray and confirmed by qRT-PCR." Insect Science 15: 405-413.
4. Junping Gao, Genhong Wang＃ (Co-first author), Sanyuan Ma, Xiaodong Xie, Xiangwei Wu, Xingtan Zhang, Yuqian Wu, Ping Zhao and Qingyou Xia (2015). CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum. Plant Mol Biol, 87, 99-110.
5. Xiaodong Xie, Genhong Wang＃ (Co-first author), Ling Yang, Tingcai Cheng, Junping Gao, Yuqian Wu and Qingyou Xia (2015) Cloning and characterization of a novel Nicotiana tabacum ABC transporter involved in shoot branching. Physiol Plant, 153, 299-306.
6. Xia, Q., D. Cheng, J. Duan, G. Wang, T. Cheng, X. Zha, C. Liu, P. Zhao, F. Dai, Z. Zhang, N. He, L. Zhang and Z. Xiang (2007). "Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori." Genome Biol 8(8): R162.
7. Xingtan Zhang, Mengyun Nie, Qian Zhao, Yuqian Wu, Genhong Wang and Qingyou Xia (2015) Genome-wide patterns of genetic variation among silkworms. Mol Genet Genomics, 290, 1575-87.
8. Xingtan Zhang, Genhong Wang, Junping Gao, Mengyu Nie, Wenshan Liu and Qingyou Xia (2016) Functional analysis of NtMPK2 uncovers its positive role in response to Pseudomonas syringae pv. tomato DC3000 in tobacco. Plant Mol Biol, 90, 19-31.
9. Xiaodong Xie, Tingcai Cheng, Genhong Wang, Jun Duan, Weihuan Niu and Qingyou Xia (2012) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in the silkworm, Bombyx mori. Mol Biol Rep, 39, 7281-91.
10. Zhao, P., Genhong Wang, Z. M. Dong, J. Duan, P. Z. Xu, T. C. Cheng, Z. H. Xiang and Q. Y. Xia (2010). "Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori." BMC Genomics 11: 405.
11. Jiang, L., G. Wang, T. Cheng, Q. Yang, S. Jin, G. Lu, F. Wu, Y. Xiao, H. Xu and Q. Xia (2012). "Resistance to Bombyx mori nucleopolyhedrovirus via overexpression of an endogenous antiviral gene in transgenic silkworms." Arch Virol.
12. Zhao, P., Z. Dong, J. Duan, G. Wang, L. Wang, Y. Li, Z. Xiang and Q. Xia (2012). "Genome-wide identification and immune response analysis of serine protease inhibitor genes in the silkworm, Bombyx mori." PLoS One 7(2): e31168.
13. Jiang, L., T. Cheng, P. Zhao, Q. Yang, G. Wang, S. Jin, P. Lin, Y. Xiao & Q. Xia (2012) Resistance to BmNPV via overexpression of an exogenous gene controlled by an inducible promoter and enhancer in transgenic silkworm, Bombyx mori. PLoS One, 7, e41838.
14. Jiang, L., P. Zhao, G. Wang, T. Cheng, Q. Yang, S. Jin, P. Lin, Y. Xiao, Q. Sun & Q. Xia (2012) Comparison of factors that may affect the inhibitory efficacy of transgenic RNAi targeting of baculoviral genes in silkworm, Bombyx mori. Antiviral Res, 97, 255-263.
15. Jiang, L., P. Zhao, T. Cheng, Q. Sun, Z. Peng, Y. Dang, X. Wu, G. Wang, S. Jin, P. Lin & Q. Xia (2013) A transgenic animal with antiviral properties that might inhibit multiple stages of infection. Antiviral Res, 98, 171-3.
16. Xingtan Zhang, Tingcai Cheng, Genhong Wang, Yafei Yan, Qingyou Xia(2012). Cloning and evolutionary analysis of tobacco MAPK gene family. Mol Biol Rep. DOI 10.1007/s11033-012-2184-9.
17. The International Silkworm Genome, C. (2008) The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochem Mol Biol, 38, 1036-45. (the 28th author in the Chinese group).
18. Cheng, D., Q. Xia, J. Duan, L. Wei, C. Huang, Z. Li, G. Wang and Z. Xiang (2008). "Nuclear receptors in Bombyx mori: Insights into genomic structure and developmental expression." Insect Biochem Mol Biol 38(12): 1130-7.
19. 王根洪, 祝慧敏, 罗会松, 王轲轲, 杨小波, 蒋亮, 夏庆友 (2011). "细菌表达dsRNA介导的家蚕FTZ-F1基因的RNA干扰." 昆虫学报 54(5): 596-601.
20. 王根洪, 刘春, 杨远萍, 吴雪峰, 夏庆友 (2005). "siRNA介导的家蚕ABC转运蛋白相关基因的干涉研究." 蚕业科学(2): 117-120,i001.
21. 艾均文, 王根洪, 李艳红, 余泉友, 张学松, 朱勇, 向仲怀. (2008). "家蚕P450基因CYP18A1的克隆、序列分析及其表达谱研究." 昆虫学报 3: 237-245.
22.王振兴, 王璞, 姚玲, 曾智东, 徐汉福, 段军, 王根洪, 夏庆友 (2006). "家蚕细胞凋亡相关基因BmlCAD的克隆、序列和功能分析及其在精巢中特异表达的初步研究." 遗传(7): 838-844.
23. 徐汉福, 王 峰, 王根洪, 段晓利, 马三垣, 夏庆友 (2011). "家蚕Poly(A)结合蛋白基因BmPABP的克隆及序列与功能分析." 蚕业科学 37(3): 412-418.
24. 杨远萍, 刘春, 王子龙, 王根洪, 夏庆友 (2006). "家蚕组织蛋白酶D基因的克隆、序列分析及其表达谱研究." 昆虫学报(2): 172-178.
联系地址：重庆市北碚区西南大学（南区）家蚕基因组生物学国家重点实验室，400716
电 话： 023-68251573
传 真： 023-68250099
E-mail：wanggh168@swu.edu.cn