刘华伟
发布时间: 2018-08-04 14:59:52   作者:本站编辑   来源: 本站原创   浏览次数:



博士,博士后

 

简历:

2018.7-至今    西南大学博士后

2012.9-2018.6  西南大学生物化学与分子生物学专业,硕博连读,理学博士

2008.9-2012.6  河南大学生物技术专业,本科,理学学士

 

主要科研领域与方向:

1. 家蚕丝氨酸蛋白酶及其抑制剂的功能研究

2. 昆虫变态发育与免疫调控研究

 

科学成就:

鉴定并调查了家蚕clip丝氨酸蛋白酶的种类和表达模式,证实该类蛋白酶参与家蚕的变态蜕皮过程,并阐明了serpin类蛋白酶抑制剂通过clip丝氨酸蛋白酶参与负调控家蚕先天免疫过程。目前已发表学术论文10余篇,主持和参研了多个国家、省部级与学校的科研项目。

 

代表性论文/论著:

1. Liu H W, Wang L L, Tang X et al. Proteomic analysis of Bombyx mori molting fluid: Insights into the molting process[J]. Journal of Proteomics, 2018, 173:115-125.

2. Liu H W, Wang L L, Meng Z et al. A clip domain serine protease involved in moulting in the silkworm, Bombyx mori: cloning, characterization, expression patterns and functional analysis.[J]. Insect Mol. Biol, 2017, 26(5): 507-521.

3. Liu H W, Li Y S, Tang X et al. A midgut-specific serine protease, BmSP36, is involved in dietary protein digestion in the silkworm, Bombyx mori.[J]. Insect Sci, 2017, 24(5): 753-767.

4. 刘华伟, 李游山, 唐新,. 家蚕丝氨酸蛋白酶BmSP141的表达特征及对饥饿的响应[J]. 中国农业科学, 2016, 49(6):1207-1218.

5. Wang L L, Liu H W, Fu H Y et al., Silkworm serpin32 functions as a negative-regulator in prophenoloxidase activation.[J]. Dev Comp Immunol, 2018, doi: 10.1016/j.dci.2018.10.006.

6. Li Y S, Liu H W, Zhu R et al. Loss of second and sixth conserved cysteine residues from trypsin inhibitor-like cysteine-rich domain-type protease inhibitors in Bombyx mori may induce activity against microbial proteases.[J]. Peptides, 2016, 86: 13-23.

7. Li Y S, Liu H W, Zhu R et al. Protease inhibitors in Bombyx mori silk might participate in protecting the pupating larva from microbial infection.[J]. Insect Sci, 2016, 23(6): 835-842.

8. Li Y S, Dong Z M, Liu H W et al. The fungal-resistance factors BmSPI38 and BmSPI39 predominantly exist as tetramers, not monomers, in Bombyx mori.[J]. Insect Mol. Biol, 2018, doi: 10.1111/imb.12504.

9. Li Y S, Zhao P, Liu H W et al. TIL-type protease inhibitors may be used as targeted resistance factors to enhance silkworm defenses against invasive fungi.[J]. Insect Biochem. Mol. Biol, 2015, 57: 11-9.

10. Guo X M, Dong Z M, Zhang Y, Li Y S, Liu H W, et al. Proteins in the cocoon of silkworm inhibit the growth of Beauveria bassiana.[J]. PloS ONE, 2016, 11(3), e0151764.

 

联系地址:重庆市北碚区西南大学(南区)家蚕基因组生物学国家重点实验室,400716

Emailhwliu096@swu.edu.cn