王元成
发布时间: 2018-08-04 14:59:35   作者:本站编辑   来源: 本站原创   浏览次数:




博士,博士后

 

简历:

2018.7-至今,西南大学博士后

2012.9-2018.6 西南大学遗传学专业,硕博连读,理学博士

2008.9-2012.6 西南大学蚕学专业,本科,农学学士

 

主要科研领域与方向:

  1. 医用蚕丝蛋白生物材料的创制与应用研究

  2. 智能蚕丝生物材料的研究

 

科学成就

建立并优化了能够在家蚕丝腺与蚕丝中高效特异性表达多个外源靶标蛋白的多基因表达系统;遗传改良出既具有促进伤口愈合又有抗炎生物活性的新型蚕丝材料;培育出新的家蚕品系10余个;在Acta biomaterialiaScientific ReportsInt J Mol Sci等多个国际知名SCI期刊上发表学术论文10余篇;申请国家发明专利5个;主持或主研多个国家、省部级与学校的科研项目

 

代表性论文/论著:

  1. Yuancheng Wang#, Feng Wang#, et al. 2A self-cleaving peptide-based multi-gene expression system in the silkworm Bombyx mori[J] Sci Rep. 2015, 5:16273. doi: 10.1038/srep16273. IF5.2278,引用31次,他引28次)

  2. Yuancheng Wang#, Feng Wang#, et al. Genetically engineered bi-functional silk material with improved cell proliferation and anti-inflammatory activity for medical application, Acta Biomaterialia(In press)

  3. Feng Wang, Yuancheng Wang, et al. Fabrication of the FGF1-functionalized sericin hydrogels with cell proliferation activity for biomedical application using genetically engineered Bombyx mori (B. mori) silk, Acta Biomater 7061(18) (2018) doi: 10.1016.

  4. Wenjing Chen, Fang Wang, Yuancheng Wang, et al, Transgenic Silkworm-Based Silk Gland Bioreactor for Large Scale Production of Bioactive Human Platelet-Derived Growth Factor (PDGF-BB) in Silk Cocoons, Int J Mol Sci 19(9) (2018) 2533.

  5. Feng Wang, Hanfu XuYuancheng Wanget al. Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application[J]. Acta Biomater. 2014 Dec;10(12):4947-4955.

  6. Feng Wang, Riyuan Wang, Yuancheng Wang, et al. Large-scale production of bioactive recombinant human acidic fbroblast growth factor in transgenic silkworm cocoons[J]. Sci Rep. 2015, 5:16323.DOI: 10.1038/srep16323.

  7. Feng Wang, Riyuan Wang, Yuancheng Wang, et al. Remobilizing deleted piggyBac vector post‑integration for transgene stability in silkworm[J]. Mol Genet Genomics, 2015, 290:1181–1189.

  8. Hanfu Xu, Yuanyuan Liu, Feng Wang,Lin YuanYuancheng Wang, et al. Overexpression and functional characterization of an Aspergillus niger phytase in the fat body of transgenic silkworm, Bombyx mori[J]. Transgenic Res. 2014 ,23(4):669-77.

  9. Hanfu Xu,  Lin Yuan, Feng WangYuancheng Wang, et al. Overexpression of recombinant infectious bursal disease virus (IBDV) capsid protein VP2 in the middle silk gland of transgenic silkworm[J]. Transgenic Research, 2014 23(5):809-16.

  10. Hanfu Xu, Dangjun Deng, Lin YuanYuancheng Wang, et al. Identification of a functional element in the promoter of the silkworm (Bombyx mori) fat body-specific gene Bmlp3[J]. Gene. 2014,546(1):129-34.

  11. Feng Wang, Sanyuan Ma, Hanfu Xu, Jun DuanYuancheng Wang, et al. High-efficiency systemfor construction and evaluation  of  customized TALENs for silkworm genome editing[J]. Mol Genet Genomics. 2013,288(12):683-90.

  12. Feng Wang, Hanfu Xu, Lin Yuan, Sanyuan MaYuancheng Wang,et al. An optimized sericin-1 expression system for mass-producing recombinant proteins inthe middle silk glands of transgenic silkworms[J]. Transgenic Res. 2013,22(5):925-38.


 

联系地址:重庆市北碚区西南大学(南区)家蚕基因组生物学国家重点实验室,400716

E-mailwyc123456@swu.edu.cn